Publications
Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma.
Cheng Y, Gunasegaran B, Singh HD, Dutertre CA, Loh CY, Lim JQ, Crawford JC, Lee HK, Zhang X, Lee B, Becht E, Lim WJ, Yeong J, Chan CY, Chung A, Goh BKP, Chow PKH, Chan JKY, Ginhoux F, Tai D, Chen J, Lim SG, Zhai W, Choo SP, Newell EW.
Immunity. 2021 Aug 10;54(8):1825-1840.e7. doi: 10.1016/j.immuni.2021.06.013.
Myeloid Cells Are Enriched in Tonsillar Crypts, Providing Insight into the Viral Tropism of Human Papillomavirus.
Mattox AK, Roelands J, Saal TM, Cheng Y, Rinchai D, Hendrickx W, Young GD, Diefenbach TJ, Berger AE, Westra WH, Bishop JA, Faquin WC, Marincola FM, Pittet MJ, Bedognetti D, Pai SI.
Am J Pathol. 2021 Oct;191(10):1774-1786. doi: 10.1016/j.ajpath.2021.06.012.
Effects of Hepatitis B Surface Antigen on Virus-Specific and Global T Cells in Patients With Chronic Hepatitis B Virus infection.
Le Bert N, Gill US, Hong M, Kunasegaran K, Tan DZM, Ahmad R, Cheng Y, Dutertre CA, Heinecke A, Rivino L, Tan A, Hansi NK, Zhang M, Xi S, Chong Y, Pflanz S, Newell EW, Kennedy PTF, Bertoletti A.
Gastroenterology. 2020 Aug;159(2):652-664. doi: 10.1053/j.gastro.2020.04.019.
Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage.
Dress RJ, Dutertre CA, Giladi A, Schlitzer A, Low I, Shadan NB, Tay A, Lum J, Kairi MFBM, Hwang YY, Becht E, Cheng Y, Chevrier M, Larbi A, Newell EW, Amit I, Chen J, Ginhoux F.
Nature Immunology. 2019 Jul;20(7):852-864. doi: 10.1038/s41590-019-0420-3.
Multifactorial heterogeneity of virus-specific T cells and association with the progression of human chronic hepatitis B infection.
Cheng Y, Zhu YO, Becht E, Aw P, Chen J, Poidinger M, de Sessions PF, Hibberd ML, Bertoletti A, Lim SG, Newell EW.
Science Immunology. 2019 Feb 8;4(32). doi: 10.1126/sciimmunol.aau6905.
Reverse-engineering flow-cytometry gating strategies for phenotypic labelling and high-performance cell sorting.
Becht E, Simoni Y, Coustan-Smith E, Evrard M, Cheng Y, Ng LG, Campana D, Newell EW.
Bioinformatics. 2019 Jan 15;35(2):301-308. doi: 10.1093/bioinformatics/bty491.
Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation.
Rivino L, Le Bert N, Gill US, Kunasegaran K, Cheng Y, Tan DZ, Becht E, Hansi NK, Foster GR, Su TH, Tseng TC, Lim SG, Kao JH, Newell EW, Kennedy PT, Bertoletti A.
J Clin Invest. 2018 Feb 1;128(2):668-681. doi: 10.1172/JCI92812.
Optimization of mass cytometry sample cryopreservation after staining.
Sumatoh HR, Teng KW, Cheng Y, Newell EW.
Cytometry A. 2017 Jan;91(1):48-61. doi: 10.1002/cyto.a.23014.
Mass cytometry: blessed with the curse of dimensionality.
Newell EW and Cheng Y.
Nature Immunology. 2016 Jul 19;17(8):890-5. doi: 10.1038/ni.3485.
Deep Profiling Human T Cell Heterogeneity by Mass Cytometry.
Cheng Y and Newell EW.
Adv Immunol. 2016;131:101-34. doi: 10.1016/bs.ai.2016.02.002.
Categorical Analysis of Human T Cell Heterogeneity with One-Dimensional Soli-Expression by Nonlinear Stochastic Embedding.
Cheng Y, Wong MT, van der Maaten L, Newell EW.
J Immunol. 2016 Jan 15;196(2):924-32. doi: 10.4049/jimmunol.1501928.
Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes.
Boettler T, Schneider D, Cheng Y, Kadoya K, Brandon EP, Martinson L, von Herrath M.
Cell Transplant. 2016;25(3):609-14. doi: 10.3727/096368915X688939.
Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes.
Van Belle TL, Pagni PP, Liao J, Sachithanantham S, Dave A, Bel Hani A, Manenkova Y, Amirian N, Cheng Y, Morin B, Zhang H, Campbell IL, von Herrath MG.
J Autoimmun. 2014 Dec;55:24-32. doi: 10.1016/j.jaut.2014.02.002.
Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.
Boettler T, Choi YS, Salek-Ardakani S, Cheng Y, Moeckel F, Croft M, Crotty S, von Herrath M.
J Immunol. 2013 Nov 15;191(10):5026-35. doi: 10.4049/jimmunol.1300013.
The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes.
Boettler T, Pagni PP, Jaffe R, Cheng Y, Zerhouni P, von Herrath M.
J Autoimmun. 2013 Aug;44:40-8. doi: 10.1016/j.jaut.2013.05.002.
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.
Nebbia G, Peppa D, Schurich A, Khanna P, Singh HD, Cheng Y, Rosenberg W, Dusheiko G, Gilson R, ChinAleong J, Kennedy P, Maini MK.
PLoS One. 2012;7(10):e47648. doi: 10.1371/journal.pone.0047648. Epub 2012 Oct 24.
OX40 facilitates control of a persistent virus infection.
Boettler T, Moeckel F, Cheng Y, Heeg M, Salek-Ardakani S, Crotty S, Croft M, von Herrath MG.
PLoS Pathog. 2012 Sep;8(9):e1002913. doi: 10.1371/journal.ppat.1002913.
TGF-β blockade does not improve control of an established persistent viral infection.
Boettler T, Cheng Y, Ehrhardt K, von Herrath M.
Viral Immunol. 2012 Jun;25(3):232-8. doi: 10.1089/vim.2011.0079.
Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.
Fousteri G, Jasinski J, Dave A, Nakayama M, Pagni P, Lambolez F, Juntti T, Sarikonda G, Cheng Y, Croft M, Cheroutre H, Eisenbarth G, von Herrath M.
Diabetes. 2012 May;61(5):1169-79. doi: 10.2337/db11-0671.